Candidate genes in polycystic ovary syndrome

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منابع مشابه

FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome.

BACKGROUND Human homologs (FEM1A, FEM1B, FEM1C) of nematode sex determination genes are candidate genes for polycystic ovary syndrome (PCOS). We previously identified a FEM1A mutation (H500Y) in a woman with PCOS; FEM1B has been implicated in insulin secretion. METHODS Women with and without PCOS (287 cases, 187 controls) were genotyped for H500Y and six FEM1A single nucleotide polymorphisms ...

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Polycystic ovary syndrome. Polycystic ovary syndrome.

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UNILATERAL POLYCYSTIC OVARY SYNDROME

Two-hundred and seventeen subjects underwent transvaginal ultrasound -17 (8%) had unilateral polycystic ovary (PCO). Twelve percent of subjects with unilateral scan-pea had oligomenorrhea, 24% were amenorrheic, 23% were hirsute and 29% had acne. Biochemical parameters were compared between subjects with unilateral scan- PCO and those with bilateral scan- PCO (n=200) as well as a group of s...

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Harnessing Expression Data to Identify Novel Candidate Genes in Polycystic Ovary Syndrome

Novel pathways in polycystic ovary syndrome (PCOS) are being identified in gene expression studies in PCOS tissues; such pathways may contain key genes in disease etiology. Previous expression studies identified both dickkopf homolog 1 (DKK1) and DnaJ (Hsp40) homolog, subfamily B, member 1 (DNAJB1) as differentially expressed in PCOS tissue, implicating them as candidates for PCOS susceptibilit...

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Major Epigenetic Changes in Polycystic Ovary Syndrome

Introduction: Polycystic Ovary Syndrome (PCOS) is one of the most common causes of female infertility. The etiology of this condition is complex. Various genetic and environmental factors have been identified in the pathogenesis of PCOS. The prevalence of this syndrome among Iranian females has been reported between 7.1% to 14.6%. Common symptoms include irregular menstruation, infertility, ova...

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ژورنال

عنوان ژورنال: Human Reproduction Update

سال: 2001

ISSN: 1460-2369,1355-4786

DOI: 10.1093/humupd/7.4.405